Background: A significant and common category of mammals, rodents can be either native or brought to other parts of the world. Their damage to crops, the poisons used to control them, the social issues brought on by their close proximity to human habitation, and the health issues resulting from their role as zoonotic disease carriers all contribute to economic problems. This research investigated the rodenticidal and toxicological studies of Piptadeniastrum africanum and Euphorbia kamerunica against albino rat. Results: This study showed that, in comparison to the control group, the mean weight of the Albino rats treated with ethanolic extracts of P. africanum and E. kamerunica Pax significantly decreased. Acute toxicity revealed that after 72 hours, ethanolic extracts of P. africanum and E. kamerunica Pax at 15ml had 67% and 50% mortality respectively. Furthermore, at 96hours both extracts had 83.3% and 100% mortality respectively. There was decrease in the Hb, RBC and PCV from the control. A potential explanation for the experimental rats' illogical behaviour, restlessness, and eventual death is suggested by this discovery. Conclusion: As indicated by an increase in WBC and lymphocytes, the study's findings imply that the ethanolic extracts of P. africanum and E. kamerunica Pax may have compromised oxygen transport and adversely affected the exposed rats' defence mechanisms. Increases in the concentrations of the feed composed with P. africanum and E. kamerunica Pax resulted in increased activity of ALP, AST, and ALT, which are markers of liver damage