ostpartum depression (PPD) remains one of the most underrecognized and neglected maternal health challenges, particularly in low- and middle-income countries such as Nigeria, despite its prevalence and severity. During the postpartum period, attention typically centers on maternal physical recovery and newborn immunization, with minimal emphasis on maternal mental health. This oversight, compounded by cultural taboos surrounding women's emotional distress, leaves many affected women undiagnosed and untreated, suffering in isolation. This descriptive study employed both primary and secondary data sources. Primary data were collected via structured questionnaires administered to nursing mothers at immunization clinics. Secondary data were drawn from scholarly literature, including library books, dictionaries, commentaries, published and unpublished materials, and online resources. Nursing mothers attending immunization clinics in Oyo East Local Government Area demonstrated adequate knowledge of PPD. However, predictors of PPD were suboptimal, as most participants reported receiving little or no spousal support following childbirth. The study recommends that government agencies develop and promote PPD support programs through media campaigns to enhance public awareness and early recognition of the condition.