This study was conducted to evaluate the factors that influence fathers' attitudes toward child and adolescent immunization in the Igando Community of Lagos State. The aims were to assess their knowledge and
attitude regarding immunization and to identify the key factors shaping these attitudes. A simple random sampling method was used to select 123 fathers, out of which 120 valid responses were analysed. Data
were gathered using a self-designed questionnaire and analysed using SPSS version 23 and Microsoft Excel 2010, with results presented in frequency/percentage tables and bar charts. The findings revealed
that most fathers had limited knowledge and a generally negative attitude toward child and adolescent immunization. Key factors affecting their attitudes included fear of vaccine side effects (84.2%), cultural beliefs
(70.0%), religious influences (47.5%), guidance from healthcare providers (29.2%), and their level of education (16.7%). A statistically significant relationship was observed between educational level and knowledge of immunization (p < 0.05), as well as between knowledge and attitude towards immunization (p < 0.05). The study concluded that enhancing fathers’ knowledge and attitude towards immunization is crucial. This can be
achieved by addressing the influencing factors through targeted interventions such as community outreach by midwives, collaboration with religious and community leaders, involvement of respected male
advocates, extended clinic hours including weekends,father-friendlyhealth environments, and workplace immunization support.