OA of the knee is a major pain generator and disability creator. This study compares the effects of Mulligan Mobilization with Movement (MWM) and rigid taping on pain and functional impairments in knee OA patients. A Power of 80% and alpha level equal to 0.05 resulted in a sample size of 33 to be randomized to three groups: convention physiotherapy (Group A), MWM (Group B), and rigid taping (Group C). After four weeks, Group B had the best pain (NPRS: 8.72 ↓4.54) and ROM (37.72° ↑114.54°) improvement (p < 0.0001). The performance of MWM was found to be significantly greater than rigid taping or conventional therapy and thus appears superior for managing knee OA.