This study examined the attitudes, perceptions, and extent of utilization of modern technological innovations among nurses at Alimosho General Hospital, Lagos State. A descriptive crosssectional research design was employed. A total of 120 questionnaires were administered, all of which were completed and analyzed using Statistical Package for the Social Sciences (SPSS) version 26 and Microsoft Excel 2010. Descriptive statistics, including frequencies and percentages, were used to summarize the data, while the chi-square test was applied to assess relationships between variables at a 0.05 level of significance. The findings indicated that most respondents exhibited positive attitudes and favorable perceptions toward the use of modern technologies in nursing practice. However, the overall level of utilization was moderate, suggesting that although nurses are receptive to technological adoption, structural and institutional constraints limit optimal use in clinical settings. Hypothesis testing showed no statistically significant association between nurses’ attitudes and their utilization of technology (p = 0.900), whereas a statistically significant relationship was found between perception and utilization (p = 0.0001*). The study concluded that nurses’ perceptions exert a stronger influence on technology utilization than attitudes alone. It recommended regular training, enhanced institutional support, and appropriate motivation to improve both perceptions and practical application of healthcare technologies among nurses. Strengthening nurses’ digital competencies is expected to improve the quality and efficiency of patient care in Alimosho General Hospital, Lagos State.