This paper examines the critical role of policy synergy in driving sustainable economic growth and development across Africa. Despite the establishment of frameworks like the African Continental Free Trade Area (AFCFTA), fragmented national policies continue to hinder continental integration. This study evaluates how aligning trade, infrastructure, and fiscal policies accelerates regional development. Using a mixedmethods approach, data was collected from regional economic reports and stakeholder interviews. The findings reveal that synchronized policy execution significantly reduces trade barriers and boosts intra-African commerce. The study concludes that deliberate, harmonized legal and economic frameworks are essential to unlocking Africa's collective economic potential. This abstract outline a macro-structural policy framework for achieving sustainable continental economic growth through the strategic synchronization of trade, monetary, industrial, and digital policies across Africa. Historically, Africa’s developmental trajectory has been fragmented by 54 distinct national markets characterized by nontariff barriers, misaligned regulatory standards, volatile unconvertible currencies, and isolated infrastructure corridors. Traditional growth models built on the primary extraction and raw export of commodities leave African states acutely vulnerable to global price volatility, worsening terms of trade, and structural stagnation.