In a cycle of poor implementation of the current curriculum by a systemic overemphasis on theory and abhorrent shortage of resources and trained staff, this paper presents a framework to close this gap between the educational performance of the Nigerian population and the needs of its labor market, which has also been a source of high unemployment among the youth. The paper has identified the key difference between innovation(the act of making something new) and entrepreneurship (the process of commercializing innovation into a viable business), and has argued that science education is best placed to impart both the creative and logical skills of an innovator and the business acumen, resilience, and discipline of an entrepreneur. The paper ends with practical proposals of action that policy makers and educators can take to improve entrepreneurial motivation and skills of their students, not only to get hired in the traditional manner, but also to be self-reliant and create jobs.